Abstract
This study reports the isolation of iridoids and cycloartane glycosides from the aerial parts of Phlomoides labiosa Bunge. Six compounds were isolated and the chemical structures were identified as phlorigidoside С (1), 8-O-acetylharpagide (2), shanzhiside methyl ester (3), cyclosiversioside A (4), cyclosiversioside E (5), and cyclosiversioside C (6). Compounds 4-6 are reported for the first time in this plant. In addition, anti-inflammatory and analgesic activities of iridoid fraction were studied. The sum of iridoids (SI) with intragastric administration is 5.2 and 52.5 times less toxic, than such market drugs as analgin and diclofenac sodium, respectively. In terms of the latitude of analgesic action (LD50/ED50), the SI exceeds analgin by 19.2 times and diclofenac sodium by 16 times. The anti-inflammatory and analgesic activities of the sum of iridoids were confirmed to be effective and nontoxic, and exceed known drugs diclofenac sodium and analgin (metamizole sodium).
Graphical Abstract
![](/cms/asset/9f69ed3c-139e-4c01-989c-058875f3e411/gnpl_a_2104274_uf0001_c.jpg)
Acknowledgements
Open Access funding provided by the Qatar National Library. Authors would like to thank the ICPS (Uzbek Academy of Sciences) for providing all necessary equipment, chemicals and animals for the study. High resolution mass spectra and NMR spectra were recorded in the Department of Structural Studies of Zelinsky Institute of Organic Chemistry, Moscow.
Disclosure statement
No potential conflict of interest was reported by the authors.