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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 1
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Research Articles

A new capnosane-type diterpenoid from the South China sea soft coral Lobophytum pauciflorum

Di Zhanga Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of ChinaView further author information
,
Yueying Lib Department of Chemistry, Texas A&M University, College Station, Texas, USAView further author information
,
Xiaolei Lia Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of ChinaView further author information
,
Xiao Hana Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of ChinaView further author information
,
Zhe Wanga Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of ChinaView further author information
&
Guoqiang Lia Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of ChinaCorrespondence[email protected]
View further author information
Pages 97-102 | Received 23 Jun 2022, Accepted 24 Jul 2022, Published online: 04 Aug 2022
 
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Abstract

A new rare capnosane-type diterpenoid (1) along with two known compounds sarcophyolides D (2) and arbolide C (3), were isolated from the soft coral Lobophytum pauciflorum collected at Xisha Islands in the South China Sea. The structure of 1 was established based on comprehensive spectroscopic data, literature comparison, and quantum chemical calculations. Compound 1 exhibited moderate anti-inflammatory activities in the zebrafish model at a concentration of 20 μM.

GRAPHICAL ABSTRACT

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (Nos. U2006204, 41776136, 2181101213, 81991522, and 41876161).

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