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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 1
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Research Articles

A pair of new chromone enantiomers from Xylaria nigripes

Jing Lia Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China;b National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaView further author information
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Yue-Ping Jianga Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China;b National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaORCID Iconhttps://orcid.org/0000-0002-5820-0123View further author information
ORCID Icon,
Lan-Qing Lic School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei, ChinaView further author information
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Hong-Ping Longd The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, PR ChinaView further author information
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Hai-Tao Liua Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China;b National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaView further author information
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Rong Yanga Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China;b National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaView further author information
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Shao Liua Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China;b National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaCorrespondence[email protected] [email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-0576-8698View further author information
ORCID Icon,
Wen-Xuan Wange Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, PR ChinaCorrespondence[email protected] [email protected] [email protected]
View further author information
&
Ji-Kai Liuc School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei, ChinaCorrespondence[email protected] [email protected] [email protected]
View further author information
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Pages 128-134 | Received 31 May 2022, Accepted 28 Jul 2022, Published online: 10 Aug 2022
 
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Abstract

A pair of new chromone derivative enantiomers, (+)-xylarichromone A (1a) and (−)-xylarichromone A (1b), were isolated from the solid fermentation of Xylaria nigripes. The planar structure of 1 was determined by extensive NMR spectroscopic data, and its absolute configuration was assigned by comparison the ECD spectra with the known chromone derivatives. Compound 1 was the first chromone derivative reported from this medicinal fungus. The neuroprotective effects of 1 against oxygen and glucose deprivation (OGD) induced pheochromocytoma-12 cells (PC12) injury was investigated.

Graphical Abstract

Acknowledgements

We are grateful for the convenience for the HRMS and NMR measurement provided by the Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central Minzu University.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

The work was financially supported by National Natural Science Foundation of China (No. 81903513, 31801789), China Postdoctoral Science Foundation (No. 2020M682599), and Natural Science Foundation of Hunan Province (No. 2021JJ41000).

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