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Natural Product Research
Formerly Natural Product Letters
Volume 37, 2023 - Issue 17
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Research Articles

Three new compounds with their anti-glioma effects from the roots of Arnebia guttata Bunge

Yu-Mei Yana Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of the Planting and Development of Astragalus Membranaceus of the Geoherbs, Baotou, ChinaView further author information
,
Lin-Jun Zoub Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. ChinaView further author information
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Min-Hui Lia Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of the Planting and Development of Astragalus Membranaceus of the Geoherbs, Baotou, China;c Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, ChinaORCID Iconhttps://orcid.org/0000-0002-5366-8464View further author information
ORCID Icon,
Zhao-Cui Sunb Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. ChinaView further author information
,
Min Zhanga Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of the Planting and Development of Astragalus Membranaceus of the Geoherbs, Baotou, ChinaView further author information
,
Xu-Dong Xub Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. ChinaCorrespondence[email protected]
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&
Chun-Hong Zhanga Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of the Planting and Development of Astragalus Membranaceus of the Geoherbs, Baotou, China;c Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, ChinaCorrespondence[email protected]
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Pages 2817-2823 | Received 04 Mar 2022, Accepted 07 Oct 2022, Published online: 20 Oct 2022
 
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Abstract

Three new compounds, arneatas A-C (1–3), together with three known compounds (4–6) were isolated from the roots of Arnebia guttata Bunge. The structures were established on the basis of extensive spectroscopic data including NMR and HRESIMS. All the new compounds (1–3) were tested for their cytotoxic activity against two glioma cell lines (U118-MG and U373-MG) in vitro after treatment for 48 h. Compound 1 exhibited moderate cytotoxic activity against U118-MG and U373-MG glioma cell lines, with IC50 values of 10.4 and 17.5 µM, respectively.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The key project at central government level: the ability establishment of sustainable use for valuable Chinese medicine resources No: 2060302 Graduate student scientific research innovation projects in Baotou Medical College No: bycx2021010 Inner Mongolia Autonomous Region Chinese Medicine (Mongolian Medicine) Young and Middle aged Leading Talents Cultivation Project NO: 2022-[RC001] This work was supported by the key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources under Grant [No: 2060302]; Graduate student scientific research innovation projects in Baotou Medical College [No: bycx2021010]; Inner Mongolia Autonomous Region Chinese Medicine (Mongolian Medicine) Young and Middle aged Leading Talents Cultivation Project NO: 2022-[RC001]

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