Cytotoxic flavonoids from the leaves of Callicarpa nudiflora hook

Abstract

A new flavonoid glycoside, luteolin-3′-O-β-D-6″-acetyl glucopyranoside (1), along with six known flavonoids, were isolated from the leaves of Callicarpa nudiflora Hook. The structures of the isolated compounds were established on the basis of extensive spectroscopic analyses. Compound 6 exhibited potent cytotoxicity and compounds 1 and 7 exhibited moderate cytotoxicity against human hepatocellular carcinoma SMMC-7721 cells.

Graphical Abstract

Keywords:

• Callicarpa nudiflora Hook
• luteolin-3′-O-β-D-6″-acetyl glucopyranoside
• pachypodol
• hepatocellular carcinoma
• cytotoxicity

Acknowledgements

We would like to acknowledge the NMR measurements by the Modern Analysis and Testing Center of CSU and Dan-gang Shangguan of Medical Department, Hunan Cancer Hospital to provide test platform to assay the bioactivity.

Disclosure statement

No potential conflicts of interest was reported by the authors.

Additional information

Funding

This study was supported by Natural Science Foundation of Hunan province (2021JJ30466), Outstanding youth project of Education Department of Hunan Province (19B363), Scientific research project of Changsha science and technology bureau (kq2202258), 2022 Intra Institutional Open Fund of School of Medicine, Hunan Normal University (KF2022001) and Undergraduate Innovative Experiment Program of Hunan Province (2020049).