Investigation on the chemical constituents of the marine-derived fungus strain Aspergillus brunneoviolaceus MF180246

Abstract

Aspergillus have been proven to be excellent resources for new natural products. During our systematic biodiversifying new compounds from marine derived fungi, one novel compound, asperbrunneo acid (1), along with seven bistetrahydroxanthone analogues, secalonic acid D (2), secalonic acid F (3), secalonic acid F1 (4), secalonic acid H (5), penicillixanthone A (6), chrysoxanthone C (7), and asperdichrome (8), one ketodivinyllactonic steroid, herbarulide (9), as well as one tyrosine-derived compound, aspergillusol A (10), were isolated from the marine-derived fungus Aspergillus brunneoviolaceus MF180246. These structures were elucidated by HRMS, 1 D and 2 D NMR analysis. Compound 1 possessed the first reported new carbon skeleton natural product. Compounds 1, 4, 5, 6, 7 and 8 showed antibacterial activity against Staphylococcus aureus with minimum inhibitory concentration values of 200, 25, 50, 6.25, 50, and 25 µg/ml, respectively.

Graphic Abstract

Keywords:

• Marine-derived fungus
• Aspergillus brunneoviolaceus
• Staphylococcus aureus

Disclosure statement

The authors declare that they have no conflicts of interest.

Additional information

Funding

This work was funded by grants from the National Natural Science Foundation of China (81973204), the Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA (MBSMAT-2019-06), and Research Foundation for Advanced Talents of Beijing Technology and Business University (19008021176).