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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 5
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Research Articles

Chemical constituents from the aerial parts of Rubia cordifolia L. with their NO inhibitory activity

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Pages 711-718 | Received 09 Nov 2022, Accepted 10 Mar 2023, Published online: 27 Mar 2023
 

Abstract

A new naphthoquinone derivative (1) together with twenty-three known compounds (224), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 113 were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 2-6 exhibited significant inhibitory activities with IC50 values of 21.37, 13.81, 24.56, 20.32, and 30.08 μmol·L−1, respectively.

Graphical Abstract

Author contributions

Conceptualization, Liu S.J. and Luo H.; methodology, Luo H.; software, Fang W.T.; validation, Zhang H., Li Y.; investigation, Fang W.T., Luo. H., Kong Q.H., and Zhang H.; resources, Fang C.W.; writing—original draft preparation, Luo H., Fang W.T.; writing—review and editing, Luo H., Zhang H.; supervision, Fang C.W.; project administration, Liu S.J.; funding acquisition, Liu S.J.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was funded by National Administration of Traditional Chinese Medicine.

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