Caffeoylquinic acids protect against alcoholic liver injury and rare C₁₀ acetylenic acids from Erigeron breviscapus

Abstract

Three new compounds (1–2, 4) along with ten known ones (3, 5–13), were isolated from the whole plant of Erigeron breviscapus. Compounds 1 and 2, two novel C₁₀ acetylenic acids and compound 4, a jasmone glucoside were elucidated by the detailed analysis of 1D and 2D NMR, HRESIMS spectra, and experimental and calculated electronic circular dichroism (ECD). Compounds 1–3 represent the first example of acetylenic acids incorporating C₁₀ skeleton from E. breviscapus. In addition, the antioxidant effects of all compounds were evaluated by ferric reducing power, 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulphonate acid) (ABTS) and 2.2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. Our results indicated the significant antioxidant activity of caffeoylquinic acids. Additionally, compounds 10–11 and 13 played protective role on alcoholic liver injury cells in a dose-dependent manner.

Graphical Abstract

Keywords:

• Erigeron breviscapus
• acetylenic acid glycoside
• ECD calculation
• caffeoylquinic acids
• antioxidant activities

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was financially supported by the National Nature Science Foundation (81673324) of the People’s Republic of China, the Foundation (LJKZ0913) from the Project of Education Department of Liaoning Province of China, Career Development Support Program for Young and Middle-aged Teachers of Shenyang Pharmaceutical University (ZQN2021006) and Liaoning province Natural Science Foundation of China (2020-MS-191).