The knowns and unknowns of West Nile virus in Europe: what did we learn from the 2018 outbreak?

ABSTRACT

Introduction: West Nile virus (WNV) is a mosquito-borne human and animal pathogen with nearly worldwide distribution. In Europe, the virus is endemic with seasonal regional outbreaks that have increased in frequency over the last 10 years. A massive outbreak occurred across southern and central Europe in 2018 with the number of confirmed human cases increasing up to 7.2-fold from the previous year, and expanding to include previously virus-free regions.

Areas covered: This review focuses on potential causes that may explain the 2018 European WNV outbreak. We discuss the role genetic, ecological, and environmental aspects may have played in the increased activity during the 2018 transmission season, summarizing the latest epidemiological and virological publications.

Expert opinion: Optimal environmental conditions, specifically increased temperature, were most likely responsible for the observed outbreak. Other factors cannot be ruled out due to limited available information, including factors that may influence host/vector abundance and contact. Europe will likely experience even larger-scale outbreaks in the coming years. Increased surveillance efforts should be implemented with a focus on early-warning detection methods, and large-scale host and vector surveys should continue to fill gaps in knowledge.

KEYWORDS:

• West Nile virus
• West Nile fever
• risk factors
• disease outbreaks
• temperature

Article highlights

• In 2018, Europe experienced the largest outbreak of West Nile virus (WNV) ever recorded

• Increased temperature and precipitation conditions (wet spring followed by drought) provide the most likely explanation for the observed increase in WNV activity.

• There are clear gaps in knowledge about the transmission ecology of WNV in Europe, and future efforts should focus on better defining the enzootic cycle of transmission.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.