Objective methods to measure vestibular evoked myogenic potential response saccular tuning curves

Abstract

Objective: To detect cervical vestibular evoked myogenic potential (cVEMP) responses using objective statistical approaches and to apply this approach to estimate saccular frequency-tuning curves in volunteers and Ménière’s disease (MD) patients.

Design: Estimates of cVEMP threshold were carried out by 3 expert raters at 500 Hz and compared to objective threshold estimates (using Hotelling’s T² [HT²] and F_sp). Saccular tuning curves were objectively estimated.

Study sample: Objective and subjective estimates of cVEMP response thresholds were compared for 13 normal hearing adults. Objective measurement of saccular tuning curves was explored in 20 healthy adults and 15 patients with MD.

Results: Significant variability was seen between subjective estimates of cVEMP thresholds. Objective analysis with the HT² test was more sensitive than 2 of 3 experts in detecting responses. The measurement time of cVEMP was considerably reduced with the HT² test. Objective saccular tuning curves in volunteers showed strongest responses at 500 Hz. A flatter tuning curve was seen for MD patients.

Conclusions: There is significant variability in subjective estimations of cVEMP thresholds. Objective analysis methods are more sensitive than subjective analysis, can detect responses rapidly and have potential to reduce variability in threshold estimates, hence they appear well suited to measure cVEMP tuning curves.

Keywords:

• cVEMP response detection
• Hotelling’s T2
• Saccular frequency-tuning curves
• Ménière's disease

Disclosure statement

No potential conflict of interest was reported by the authors.