Abstract
Objective
To ensure the safety and quality of vaccines, especially the newest RNA-vaccines against COVID-19, is one of the World Health Organization’s current highest priorities.
Design
Case description.
Study sample
We report three cases of sudden unilateral tinnitus following BNT162b2 mRNA-vaccine injection, which rapidly resolved in 2 out of 3 cases.
Results
The mechanism responsible for its development remains unclear. A hypersensitivity reaction with an abnormal autoimmune response or a vasculitic event may be implicated.
Conclusions
Large-scale and well-designed studies are needed to improve surveillance of the COVID-19 vaccine and better define possible adverse reactions involving the cochleo-vestibular system and/or immunisation anxiety-related reactions.
Acknowledgments
The authors thank: Alessandro Incognito, MD and all audiometrists of Audiology Unit, Treviso Hospital, for their contribution in assisting the patients. Mauro Ramigni, MD, Local Health Unit, ULSS 2 Marca Trevigiana, Treviso, for information with regard to COVID-19 vaccine doses administered. Ms. Alison Garside for correcting the English version of the paper.
Disclosure statement
No potential conflict of interest was reported by the author(s).