Synthesis, characterization, and biological applications of pyrazole moiety bearing osmium(IV) complexes

Abstract

Osmium (IV) complexes with pyrazole nucleus containing ligands were synthesized. Os(IV) compounds were characterized using ESI-MS, ICP-OES, IR spectroscopy, electronic spectroscopy, conductance, and magnetic measurements. Whereas, ligands were characterized by heteronuclear spectroscopy, (¹H and ¹³C), IR spectroscopy, and elemental analysis. All the compounds were tested for their potential to interact with HS-DNA by absorption titration, fluorescence spectroscopy, viscosity measurement, and docking study. The quenching constant and Stern Volmer constant values were calculated using fluorescence study. The synthesized compounds were studied for in-vitro bacteriostatic and cytotoxic activities. The cancer cell line studies of all the synthesized complexes were carried out on human lung cancer cells (A549).

Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1921795 .

Graphical Abstract

Keywords:

• Pyrazole nucleus
• absorption titration
• docking
• Os(IV) complexes

Acknowledgments

The authors are thankful to the Head, Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India, for providing the laboratory facilities, U. G. C., New Delhi for providing financial assistance of UGC BSR grant No. C/2015/BSR/Chemistry/1579 and University Grant Commission under the scheme of “BSR UGC One Time Grant”, vide UGC letter No. F.25-1/2014-15 (BSR)5-100/2007(BSR)Date13/March, 2015.