Variability in CD39 and CD73 protein levels in uveal melanoma patients

Abstract

Extracellular adenosine is produced from ATP by CD39 and CD73, and can modulate tumor development by acting on cancer cells or immune cells. Adenosine metabolism has been poorly studied in uveal melanoma. We studied the protein levels of CD39 and CD73 in a small, well described cohort of patients with uveal melanoma. Our results show a high variability in the levels of the two proteins, both in positivity and in intensity. Our results suggest that similar studies on larger cohorts could determine the clinical value and the druggability of these enzymes in the given clinical setting.

Supplemental data for this article is available online at http://dx.doi.org/10.1080/15257770.2022.2032738

Keywords:

• CD73
• CD39
• immunohistochemistry
• uveal melanoma

Acknowledgements

LPJ receives funding from Olav Raagholt og Gerd Meidel Raagholts stiftelse for forskning.

Conflict of interest

The authors have no conflict of interest.

Fundings

There is no particular funding for this work.

Data availability

Data is available upon request to the authors.