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Abstract
Several studies have reported that Lactobacillus gasseri PA-3 reduces the level of serum uric acid (SUA) in patients with hyperuricemia. However, it remains unknown how PA-3 affects uric acid metabolism. In the present study, we examined effects of PA-3-containing yoghurt on uric acid metabolism in patients with marginal hyperuricemia. Sixteen patients with SUA > 357 μmol/L (marginal hyperuricemia) were enrolled. PA-3-containing yoghurt was administered for 8 weeks. Uric acid metabolism was evaluated just before and 8 weeks after the administration and at 4 weeks after the administration ended (post-administration). SUA levels after the administration were significantly lower than that before the administration and remained low at post-administration. Urinary uric acid concentration (Uur) after the administration were significantly lower than that before the administration. However, post-administration Uur levels were comparable to those before the administration. Therefore, PA-3-containing yoghurt significantly reduced the levels of SUA and Uur in patients with marginal hyperuricemia.
Conflict of interest
Dr. I. Hisatome reports having received lecturing fees from Sanwa Kagaku Kenkyusho Co. Ltd., Mochida Co. Ltd., and Fuji Yakuhin Co. Ltd., and research grants from Meiji Co., Ltd., Teijin Pharma Ltd., Fuji Yakuhin Co. Ltd and Sanwa Kagaku Kenkyusho Co. Ltd. The other authors have no conflicts of interest directly relevant to the content of this article.
Funding
The author(s) reported there is no funding associated with the work featured in this article.