Fabricate, advancement, molecular docking and DNA reactivity of preferred divalent metal(II) complexes attributing (E)-N’-((6-hydroxybenzo[d]oxazol-5-yl) methylene)isonicotinohydrazide

Abstract

A series of metal(II) complexes (M=Co (II), Ni(II) and Cu(II)) supported by Schiff base ligand (L=(E)-N’-((6-hydroxybenzo[d]oxazol-5-yl)methylene)isonicotinohydrazide) has been designed and developed from condensation of 6-hydroxybenzo[d]oxazole-5-carbaldehyde and isoniazid. The ligand (H₂L) and its metal(II) complexes were structurally characterized utilizing a variety of physicochemical and spectroscopic approaches. The study shows that Schiff bases (H₂L) act as monobasic tridentate ONO ligand and conform to octahedral geometry according to the general formula [M(HL)₂]. Furthermore, the interaction of these complexes with CT-DNA was investigated at pH = 7.2, utilizing UV–visible absorption, and viscosity measurement. In order to determine the mechanism of binding of the metal(II) complexes to the B-DNA dodecamer, docking studies were conducted using an AutoDock Vina 1.2.0 tool. The photo induced cleavage reveals that the ligand (H₂L) and its complexes have UV–visible photo nuclease properties against pUC19 DNA by agarose gel electrophoresis technique. Studies showed that the complexes evaluated firmly bind to CT-DNA via intercalative mode and provides a distinctive pattern of DNA binding.

Graphical abstract

Keywords:

• Schiff base
• isonicotinohydrazide
• metal(II) chelates
• molecular docking
• DNA reactivity

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.