The risk of relapse in breast cancer patients is associated with MMP-9 gene polymorphism: a prospective study in a sample of the Iranian population

Abstract

We investigated the association of MMP-9 rs1056628 and rs17576 polymorphisms with breast cancer (BC) relapse in a cohort of prospectively observed BC patients. The polymorphisms were genotyped in 200 BC subjects with(case) and without(control) relapse by Tetra-primer Amplification Refractory Mutation System-Polymerase Chain Reaction (T-ARMS-PCR) method. A significant association was found between the rs1056628C allele and increased risk of BC relapse (OR = 1.8, P = 0.006). Also, rs17576 allele and genotypes were shown protective effects against BC relapse. Increased risk of relapse was observed in haplotype CG (OR = 2.1, P = 0.001). Our results suggest for the first time that rs1056628 and rs17576 polymorphisms may influence BC relapse.

Keywords:

• Matrix metalloproteinase
• polymorphism
• breast cancer
• relapse
• haplotype

Acknowledgment

The authors appreciate all people who voluntarily joined the investigation.

Disclosure statement

The authors declare that they have no conflict of interest.

Author contribution

L.K. is responsible as the guarantor of integrity of the entire study, study design, literature research, data analysis, and manuscript review and editing. M.M. and SM.M. are responsible for the clinical studies, experimental studies, data acquisition, and manuscript preparation. All authors have read and agreed with the final version of this manuscript.

Additional information

Funding

This study was partly supported by Islamic Azad University, Arsanjan Branch.