Differential expression of KCNQ1 and ATP4A genes according to the sex and age in the stomach

Abstract

We compared the expression of six genes in stomach tissue samples between healthy men and women in different age groups to study sexually dimorphic gene expression. Real-Time RT-PCR was used to compare gene expression between men and women. Our results showed that the expression of KCNQ1 (p = 0.01) was significantly higher in non-menopausal women compared to post-menopausal women. In addition, the expression level of the ATP4A gene in men under 35 years was significantly higher than in men above 50 (p = 0.026). Sexually and age dimorphic gene expression in some genes throughout life may affect gastric function.

Keywords:

• Sexual dimorphism
• stomach
• gastric cancer
• KCNQ1
• ATP4A

Acknowledgements

We are grateful for their cooperation of the nurses of Imam Ali Hospital (Farokhshahr—Shahrekord Iran) in sampling.

Disclosure statement

The authors report there are no competing interests to declare.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.