Necroptosis in the pathophysiology of preeclampsia

ABSTRACT

Necroptosis is a newly-identified form of gene-regulated cell necrosis that is increasingly considered to be a pathway associated with human pathophysiological conditions. Cells undergoing necroptosis exhibit necrotic phenotypes, including disruption of the plasma membrane integrity, organelle swelling, and cytolysis. Accumulating evidence suggests that trophoblast necroptosis plays a complex role in preeclampsia (PE). However, the exact pathogenesis remains unclear. Its unique mechanisms of action in various diseases are expected to provide prospects for the treatment of PE. Therefore, it is necessary to further explore its molecular mechanism in PE in order to identify potential therapeutic options. This review examines the current knowledge regarding the role and mechanisms of necroptosis in PE and provides a theoretical basis for new therapeutic targets for PE.

KEYWORDS:

• preeclampsia
• necroptosis
• trophoblast
• cell death

Acknowledgements

The authors sincerely thank Professor Rong Zhou at West China Second University Hospital for the assistance in this review.

Disclosure statement

No potential conflict of interest was reported by the authors.

Author contributions

HY and LC gathered and prepared all data, HY, BD and CL performed the writing of the paper, and made the figures. HY performed the conceptualization and review of the paper. All authors contributed to the article and approved the submitted version.

Data availability statement

The data that support the findings of this study are available from the corresponding author.

Additional information

Funding

This work was supported by the Nanchong City-school science and technology strategic cooperation special fund project. NO.22SXQT0269.