Optimization of electrospinning parameters for producing silk fibroin/poly(ethylene oxide) nanofibers using D-optimal method

ABSTRACT

Despite the ease of the electrospinning process of synthetic polymers, the adjustment of several independent variables for natural ones is a complex procedure. In this work, the electrospinning parameters of silk fibroin (SF)/poly(ethylene oxide) (PEO) blends including tip-to-collector distance (X₁), applied voltage (X₂), flow rate (X₃) and SF/PEO ratio (X₄) were optimized using the D-optimal method. By considering the response surface plots and interaction graphs as well as observing the scanning electron microscopy (SEM) images, the optimized conditions were set as follows: X₁ = 15 cm, X₂ = 12 kV, X₃ = 1.2 mL/h and X₄ = 4. Accordingly, the electrospun SF/PEO nanofibrous sample with uniform morphology and an average diameter of 182 ± 55 nm was obtained.

摘要

尽管合成聚合物电纺丝过程比较容易，但自然聚合物的几个独立变量的调整是一个复杂的过程。在这项工作中，静电纺丝参数对丝素蛋白（SF）/聚氧化乙烯（PEO）共混物包括尖到集电极的距离（X1），电压（X2）、流量（X3）和SF / PEO率（X4）使用最优方法的优化。结合响应面图和交互图以及观察的扫描电子显微镜（SEM）图像，优化条件为：X1 = 15厘米，X2 = 12 kV，X3 = 1.2毫升/小时，X4 = 4。因此，获得了均匀形貌平均直径为182～55 nm的静电纺纳米纤维样品。

KEYWORDS:

• Silk fibroin
• poly (ethylene oxide)
• electrospinning
• morphology
• nanofiber
• D-optimal method

关键词:

• 丝素蛋白
• 聚（环氧乙烷）
• 电纺
• 形态学纳
• 米纤维
• D-最优方法