Fabrication of Cellulosic Nonwoven-Based Wound Dressings Coated with CTAB-Loaded Double Network PAMPS/PNaA Hydrogels

ABSTRACT

Novel approaches have been implemented to fabricate wound dressings including electrospinning of hydrogels, and coating-based nonwoven hydrogels. In this study, only the coating technique was studied in order to fabricate wound dressing. For this purpose, nonwoven cotton fabrics were coated with layer-by-layer PNaA (poly sodium acrylate) and poly 2-Acrylamido-2-methylpropane sulfonic acid (PAMPS). Microwave techniques were then implemented to create an antibacterial activity using cetyltrimethylammonium bromide (CTAB). For the characterization, the physical, mechanical and antibacterial properties of the different samples and to determine potential wound dressing candidates, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), swelling, and water vapor permeability (WVP) tests as well as contact angle measurements with water were performed. The application of microwave techniques using CTAB on the fabricated nonwoven-based wound dressings showed potential results of creating an efficient antibacterial activity with high fibroblast cell viability. The in vitro aspirin release experiment confirmed that the release amount depended on the number of hydrogel layers. The results of physical and mechanical tests showed that coated nonwoven with layers of hydrogels had the desired strength along breathability, flexibility, and wettability. These cumulative results indicate that the fabricated structures in this work are good potential candidates for wound dressing applications.

摘要

新的方法已经被用于制造伤口敷料, 包括水凝胶的静电纺丝和基于涂层的非织造水凝胶。在这项研究中, 为了制作伤口敷料, 只研究了涂层技术. 为此, 非织造棉织物被逐层涂覆PNaA(聚丙烯酸钠)和聚2-丙烯酰胺基-2-甲基丙烷磺酸(PAMPS). 然后采用微波技术使用十六烷基三甲基溴化铵(CTAB)产生抗菌活性. 为了表征不同样品的物理、机械和抗菌性能, 并确定潜在的伤口敷料候选者, 进行了傅里叶变换红外光谱(FTIR)、扫描电子显微镜(SEM)、溶胀和水蒸气渗透性(WVP)测试, 以及与水的接触角测量. 使用CTAB的微波技术在所制备的非织造伤口敷料上的应用显示了产生具有高成纤维细胞活性的高效抗菌活性的潜在结果. 体外阿司匹林释放实验证实, 释放量取决于水凝胶层数. 物理和机械测试的结果表明, 涂有水凝胶层的非织造布在透气性、柔韧性和润湿性方面具有所需的强度. 这些累积结果表明, 这项工作中制造的结构是伤口敷料应用的良好潜在候选者.

KEYWORDS:

• Cellulosic nonwoven-based wound dressing
• double network hydrogel
• CTAB-based antibacterial activity
• aspirin delivery
• cell viability
• cotton nonwoven

关键词:

• 纤维素非织造伤口敷料
• 双网络水凝胶
• 基于CTAB的抗菌活性
• 阿司匹林递送
• 细胞活力
• 棉非织造布

Disclosure statement

No potential conflict of interest was reported by the author(s).

Highlights

• Cellulosic nonwoven-based wound dressings containing layer-by-layer poly sodium acrylate and poly 2-Acrylamido-2-methylpropane sulfonic acid were fabricated.

• Microwave techniques were implemented to create the antibacterial activity using cetyltrimethylammonium bromide.

• The number of hydrogel coating layers changed the swelling, hydrophilicity properties and the amount of drug release.

• Coated cotton-based nonwoven with a double network of hydrogels had optimized strength at breaking, and high-water vapor permeability.

Additional information

Notes on contributors

Ali Sadeghianmaryan

Dr. Ali Sadeghianmaryan is working at the University of Memphis, department of biomedical engineering as a postdoctoral researcher. The current areas of his study are Wound dressing, Skin Scaffolding, Bone Tissue Engineering, 3D-Bioprinting, and Electrospinning. He completed his bachelor’s degree, master’s, and Ph.D. in Chemistry and Fiber science at IAU University. he studied the application of nano-bio materials for medical purposes. He is well accomplished and trained in drug delivery carriers, In Vitro cytotoxicity tests, In Vitro characterization, biocompatibility, and nano-biofabrication. Dr. Ali Sadeghianmaryan did research internships at the University of Saskatchewan, Canada, as a visiting professor in the field of 3D-Bioprinting of Chitosan to fabricate Cartilage Tissue Engineering. He has explored different skills during his professional career, such as Tissue Engineering, Scaffolding, Wound Dressing Fabrications, Polymers, and Fibers, Electrospinning, 3D-bioprinting, and Drug Delivery.