Advanced search
Publication Cover
Fetal and Pediatric Pathology Volume 41, 2022 - Issue 4
Submit an article Journal homepage
182
Views
0
CrossRef citations to date
0
Altmetric
Articles

Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease

Ferit Durankuşa Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, TurkeyCorrespondence[email protected]
,
Yakup Albayrakb Faculty of Medicine, Department of Psychiatry, Tekirdağ Namık Kemal University, Tekirdağ, Turkey
,
Yavuz Tokgözc Department of Pediatrics, Keçiören Education and Research Hospital, Health Sciences University, Ankara, Turkey
,
Ömer Faruk Beşerd Medical School, Department of Pediatric Gastroenterology, Cerrahpaşa University, İstanbul, Turkey
,
Ramazan Durankuşa Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey
,
Sebahat Çama Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey
,
Eda Sünnetçie Medical School, Department of Pediatrics, Acıbadem University, İstanbul, Turkey
,
Ömer Akarsuf Department of Microbiology, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey
,
Cemil Nuralg Department of Clinical Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, Turkey
&
Özcan Erelg Department of Clinical Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, TurkeyORCID Iconhttps://orcid.org/0000-0002-2996-3236
ORCID Icon show all
Pages 576-583 | Received 06 Mar 2021, Accepted 08 Apr 2021, Published online: 04 May 2021
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Background

The aim of the present study was to assess thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with Wilson Disease (WD) and to compare them to healthy controls. Methods: Based on the inclusion and exclusion criteria, fifteen children with WD and twenty-nine healthy children were enrolled, and serum thiol/disulfide and IMA levels were compared between groups. Results: The mean values of native and total thiols were significantly lower in the WD group than in the control group. The mean value of disulfide was significantly higher in the WD group than in the control group. The mean percentages of disulfide/total thiol and native thiol/total thiol were higher in the WD group than in the control group. The IMA value was also higher in the WD group than in the control group. Conclusion: The present study demonstrating altered thiol/disulfide parameters indicates increased oxidative stress in children with WD.

Disclosure statement

The authors have no conflict of interest to declare.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 748.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.