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Fetal and Pediatric Pathology Volume 41, 2022 - Issue 4
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Articles

Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease

Ferit Durankuşa Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, TurkeyCorrespondence[email protected]
,
Yakup Albayrakb Faculty of Medicine, Department of Psychiatry, Tekirdağ Namık Kemal University, Tekirdağ, Turkey
,
Yavuz Tokgözc Department of Pediatrics, Keçiören Education and Research Hospital, Health Sciences University, Ankara, Turkey
,
Ömer Faruk Beşerd Medical School, Department of Pediatric Gastroenterology, Cerrahpaşa University, İstanbul, Turkey
,
Ramazan Durankuşa Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey
,
Sebahat Çama Department of Pediatrics, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey
,
Eda Sünnetçie Medical School, Department of Pediatrics, Acıbadem University, İstanbul, Turkey
,
Ömer Akarsuf Department of Microbiology, Göztepe Education and Research Hospital, Istanbul Medeniyet University, İstanbul, Turkey
,
Cemil Nuralg Department of Clinical Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, Turkey
&
Özcan Erelg Department of Clinical Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, TurkeyORCID Iconhttps://orcid.org/0000-0002-2996-3236
ORCID Icon show all
Pages 576-583 | Received 06 Mar 2021, Accepted 08 Apr 2021, Published online: 04 May 2021
 
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Abstract

Background

The aim of the present study was to assess thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with Wilson Disease (WD) and to compare them to healthy controls. Methods: Based on the inclusion and exclusion criteria, fifteen children with WD and twenty-nine healthy children were enrolled, and serum thiol/disulfide and IMA levels were compared between groups. Results: The mean values of native and total thiols were significantly lower in the WD group than in the control group. The mean value of disulfide was significantly higher in the WD group than in the control group. The mean percentages of disulfide/total thiol and native thiol/total thiol were higher in the WD group than in the control group. The IMA value was also higher in the WD group than in the control group. Conclusion: The present study demonstrating altered thiol/disulfide parameters indicates increased oxidative stress in children with WD.

Disclosure statement

The authors have no conflict of interest to declare.

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