Langerhans Cell Histiocytosis in a Pediatric Patient with Simultaneous Gastrointestinal and Skin Involvement: A Case Report and Literature Review

Abstract

Background: Langerhans cell histiocytosis (LCH) has heterogeneous presentations involving single or multiple systems, but simultaneous isolated skin and gastrointestinal involvement is not common. Case report: A female infant with intermittent bloody diarrhea was unresponsive for treatment of food allergy. Histology of gastric and colonic tissues demonstrated Langerhan’s cell histiocytosis. The infant also had red rashes that were histologically proven Langerhan’s cell histiocytosis. Chemotherapy utilized vincristine, cytarabine and prednisone. The bloody diarrhea and rash completely resolved with no recurrence in the 11 months of follow-up. Conclusion: Langerhan cell histiocytosis may present with simultaneous gastrointestinal and skin involvement.

Keywords:

• Langerhans cell histiocytosis
• langerin
• chemotherapy
• gastrointestinal involvement
• case report

Authors’ contributions

JF drafted the manuscript. JC and CD revised the manuscript. JL, TH, YL, YX and MW collected and analyzed the data. All authors read and approved the final manuscript.

Consent for publication

Written informed consent for publication was obtained from the patient’s parents.

Disclosure statement

The authors report there are no competing interests to declare.

Ethics approval and consent to participate

This study was performed according to the convention of the Declaration of Helsinki. Written informed consent was obtained from all the participants.

Additional information

Funding

This work was supported by the Kunming Health Science and Technology Talent Project & Technology Center Construction Project under Grant No. 2020-SW-29.