https://orcid.org/0000-0001-8548-8874
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ABSTRACT
In the nervous system, dead cell-derived material arising from injuries and neurodegeneration is normally removed by the phagocytic activity of macrophages or glia. Failure in this process can lead to excessive inflammation and secondary neurodegeneration. During phagocytosis, engulfed material is captured into phagosomes. Maturation and subsequent fusion of these vesicles with lysosomes may utilize components of the macroautophagy pathway that has been referred to as LC3-associated phagocytosis or LAP for short.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
The work was supported by the Magyar Tudományos Akadémia [BO/00078/18]; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal [ÚNKP-20-5]; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal [NKFIH-871-3/2020]; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal [KKP129797]; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal [GINOP-2.3.2-15-2016-00032]; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal [FK132183].