A convenient four-component reaction for the synthesis of dithiocarbamates starting from naphthols in water

ABSTRACT

An efficient one-pot four-component condensation of naphthols with formaldehyde, carbon disulfide and secondary amines in water is described for the synthesis of 1-(dithiocarbamatomethyl)-2-naphthols and 2-(dithiocarbamatomethyl)-1-naphthols. By using naphthalene-2,3-diol in this protocol, the corresponding bis(dithiocarbamates) were obtained in high yields via a one-pot pseudo seven-component reaction. The reaction is characterized by a wide substrate scope, high efficiency, green solvent, catalyst-free conditions and straightforward isolation protocol. Employing this newly developed multicomponent reaction enabled the synthesis of 26 dithiocarbamates.

GRAPHICAL ABSTRACT

KEYWORDS:

• Dithiocarbamates
• 1-(dithiocarbamatomethyl)-2-naphthols
• water
• multicomponent
• catalyst-free

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

We are grateful to the research council of Kharazmi University and the Czech Academy of Sciences [grant number RVO: 61388963] for supporting this work.