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Expert Opinion on Drug Delivery Volume 17, 2020 - Issue 5
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Original Research

A versatile nanoplatform for synergistic chemo-photothermal therapy and multimodal imaging against breast cancer

Tingting Lia Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China;b Center for Information in Biology, University of Electronic Science and Technology of China, ChengduSichuan, P.R. ChinaView further author information
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Yue Genga Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. ChinaView further author information
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Hanxi Zhanga Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. ChinaView further author information
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Jing Wanga Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. ChinaView further author information
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Yi Fenga Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. ChinaView further author information
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Zhongyuan Chena Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. ChinaView further author information
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Xiaoxue Xiea Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. ChinaView further author information
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Xiang Qina Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China;b Center for Information in Biology, University of Electronic Science and Technology of China, ChengduSichuan, P.R. ChinaView further author information
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Shun Lia Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China;b Center for Information in Biology, University of Electronic Science and Technology of China, ChengduSichuan, P.R. ChinaView further author information
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Chunhui Wua Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China;b Center for Information in Biology, University of Electronic Science and Technology of China, ChengduSichuan, P.R. ChinaView further author information
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Yiyao Liua Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China;c Department of Cancer Research, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, P.R. ChinaCorrespondence[email protected] [email protected]
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Hong Yanga Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China;b Center for Information in Biology, University of Electronic Science and Technology of China, ChengduSichuan, P.R. ChinaCorrespondence[email protected] [email protected]
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Pages 725-733 | Received 15 Oct 2019, Accepted 25 Feb 2020, Published online: 03 Mar 2020
 
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ABSTRACT

Objectives

Mesoporous silica nanoparticles (MSNs) with unique advantages can combine multiple functionalities including imaging and therapeutic into one single platform that can provide personalized diagnosis and treatment. In this study, we fabricated a multifunctional nanocomplex for the delivery of a classic chemotherapy drug (Doxorubicin, DOX) and a near-infrared (NIR) dye (indocyanine green, ICG) based on mesoporous silica-coated Fe3O4 nanoparticles. Hyaluronic acid (HA) was conjugated onto the surface of the nanocomplex to respond to hyaluronidase (HAase). the final complex is short for M-MSN/HA/DI.

Methods

The successful synthesis of M-MSN-HA/DI nanocomplex was confirmed by Fourier transform infrared spectroscopy and UV–vis spectrometer. The photothermal conversion efficiency and antitumor efficiency in breast cancer bearing mice were further evaluated.

Results

M-MSN/HA/DI showed preeminent T2 MR and fluorescence (FL) imaging ability, and the release of DOX was accelerated in the presence of HAase. The nanocomplex generated high heat upon 808 nm NIR irradiation and efficiently induced apoptosis in breast cancer cells. The in vivo studies demonstrated that the final nanocomplex can inhibit tumor growth with minimal systemic toxicity upon 808 nm NIR irradiation.

Conclusion

Collectively, our work offers a preclinical proof of concept for a multifunctional drug delivery system for cancer therapy and imaging,which could achieve efficient application for cancer.

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Declaration of Interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer Disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (81671821, U19A2006, 11772088, 31700811, 11802056, 31800780, 11972111, 31900940), the China Postdoctoral Science Foundation (2018M640904, 2019T120831), the Sichuan Science and Technology Program (2019YJ0183, 2019YJ0184), and the Fundamental Research Funds for the Central Universities (ZYGX2019J117).

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