En face swept-source optical coherence tomography angiography choroidal vasculography (CVG) a tool to discriminate choroidal abnormalities in polypoidal choroidal vasculopathy

ABSTRACT

Background

Swept source optical coherence tomography angiography (SS-OCT-A) choroidal vasculography (CVG) is an imaging method which allows the evaluation of deep choroid details, being a promising too in choroidal pathologies as polypoidal choroidal vasculopathy (PCV).

Research design and methods

Cross-sectional study performed at FOSCAL International Clinic in Colombia. CVG features in patients with PCV were evaluated using SS-OCT CVG.

Results

Twenty-two eyes of 21 patients were included. The mean age was 72.7 ± 6.5 years old (range: 48.6–95.4 years old). Twelve (57.1%) patients were male. The mean number of polyps detected by SS-OCT-A CVG before treatment with anti-VEGF therapy was 2.04 ± 1.18, which decreased after treatment to 1.18 ± 0.71. This result was statistically significant (p < 0.05). All polypoidal lesions detected by B-scan were visualized using CVG. Polyp circularity and surrounding reflectivity indicated activity of disease.

Conclusion

En face SS-OCT-A CVG is an alternative tool to evaluate choroidal structure at different depths without a contrast dye, providing information for the diagnosis and follow-up of patients with PCV. This imaging modality do not pretend to replace gold standard tests in PCV as ICGA, but rather provides choroidal imaging features of PCV, when ICGA is not available.

KEYWORDS:

• Choroid
• macular degeneration
• optical coherence tomography
• polyps
• vasculography

Acknowledgments

There were not received grants or any support for this investigation.

Author contributions

Study design: JD Arias, AT Hoyos, MM Parra. Data collection: AT Hoyos, MM Parra and FJ Arango, statistical analysis: AT Hoyos, MM Parra, EJ Viteri. Final revision: JD Arias, MM Parra, JF Arevalo.

Study design: JDA, ATH, MMP. Data collection: ATH, MMP and FJA, statistical analysis: ATH, MMP, EJV. Final revision: JDA, MMP, JFA.

Declaration of interest

JDA and JFA receive research grant support from TOPCON. This work was not supported by any organization.

Declaration of interest

JD Arias and JF Arevalo receive research grant support from TOPCON. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Reviewer Disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.