The prevalence of oropharyngeal dysphagia in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

ABSTRACT

Background

Oropharyngeal dysphagia (OD) in chronic obstructive pulmonary disease (COPD) patients seriously influence the long-term prognosis of COPD patients. The aim of this study was to assess the prevalence and risk factors of OD in patients with COPD through a systematic review and meta-analysis of observational studies.

Methods

We identified all observational studies on the prevalence of OD in COPD patients by searching PubMed, Embase, the Cochrane Library, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), China National Knowledge Infrastructure (CNKI), the China Biomedical Literature Service System (CBM), the Wanfang Database, and the WeiPu (VIP) databases from database establishment to 1 December 2020.

Results

    Results of the meta-analysis showed that the prevalence of OD in COPD patients was 32.7% (95%CI=30.1, 35.4, I2=91.5%). Dyspnea, gastroesophageal reflux disease(GERD), xerostomia, sputum bacteria, poor physical capacity, poor quality of life, and high CRP level are the risk factors for OD in COPD patients.

Conclusion

: The prevalence of OD in COPD patients is high. There were some differences in OD among COPD patients with different sex, ages, continents, evaluation methods, patient source and COPD exacerbation.

KEYWORDS:

• COPD
• oropharyngeal dysphagia
• prevalence
• risk factors
• systematic review

Authorship statement

Literature search:Wenyan Li, Jin Liu, Rongjing Yuan, Mingjing Gao, QingLing Su

Data collection:Wenyan Li, QingLing Su, Yetong Wang

Study design:Wenyan Li, Fengwa Zhang, Yanhong Wang, Mingjing Gao

Analysis of data:Wenyan Li, Jin Liu, Rongjing Yuan, Mingjing Gao

Manuscript preparation:Wenyan Li, Fengwa Zhang, Yanhong Wang

Wrote the paper:Wenyan Li, Yanhong Wang

Disclosure statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

The study was funded by the National Natural Science Foundation of China (No.71804064).