Hepatotoxicity of aflatoxin B1 and its oxidative effects in wood dust Egyptian exposed workers

Abstract

The goal of the present study is to estimate the oxidative effects of AFB1 induced hepatotoxicity in furniture wood dust exposed workers. A cross-sectional comparative study was designed for comparing AFB1/albumin (AFB1/alb) levels and liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)], malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) in 88 furniture workers and 78 controls not occupationally exposed to wood dust. The AFB1/Alb, AST, ALT, MDA, and GPx were significantly higher; while, CAT significantly reduced in workers compared with controls. There was a significant correlation between AFB1/Alb and MDA level with the liver enzymes among both groups. CAT was inversely correlated with AFB1/Alb and the liver enzymes, and GPx was inversely correlated with AST in the workers. It was concluded that wood dust exposure is associated with raised serum levels of AFB1 and oxidative stress.

Keywords:

• Aflatoxin B1
• antioxidants
• liver enzymes
• oxidative stress
• wood dust
• workers

Acknowledgment

The authors acknowledge the scientific role of Prof. abdel Hameed Awad and Dr.Yousra Saaed, Air Pollution Research Department, National Research Centre, for conducting the environmental measurement.