https://orcid.org/0000-0002-7122-375X
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Abstract
Olives (Olea europaea) have natural phytochemical compounds that are of great importance for their potential beneficially health effects. This study aimed to evaluate the effects of olive leaf powder (OLP) on insulin production and circulating adipokines in streptozotocin-induced diabetic rats. Forty Wistar-albino male rats, weighing 200–225 g were divided into four groups (n = 10); group I: Normal healthy rats received balanced diet; group II: Diabetic control rats receiving balanced diet; group III: Diabetic rats receiving balanced diet + standard antidiabetic drugs (metformin, 600 mg/bw) and group four: Diabetic rats received diet supplemented with 2.0% OLP. The experiment was conducted for four weeks. Our results showed that the consumption of 2.0% OLP decreased serum glucose, triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels, whereas serum high density lipoprotein (HDL) level was increased. OLP supplementation also inhibited the atherogenic index [AI; log (TG/HDL-C) and atherogenic coefficient (AC)] levels relative to those of the untreated diabetic group. Moreover, OLP increased serum adiponectin concentration, and decreased serum leptin concentration. Liver and kidney functions were also attenuated by OLP. This finding also implies that OLP can play an important role in the treatment and delay of diabetic complications.
Declaration of interest
The authors report that they have no conflicts of interest.
Author’s contribution
HMA conceived the idea for the study, research design and measurement of the tested ELISA. MAE and SBG were involved in sample collection and share the analysis of the study. HMA wrote the paper. SSK and MMA followed the experimental duration and share the analysis of the study. All authors edited and approved the final version of the manuscript.
Additional information
Notes on contributors
Hala M. Abdelkarem
Hala M. Abdelkarem, PhD, is a professor Dr. of the Department of chemistry of the faculty of Science at University of Imam Abdulrahman Bin Faisal, Dammam, Saudi Arabia. Her area of expertise is biochemical nutrition. Her main research on clinical nutrition of obesity, diabetic mellitus and management of osteoporosis in menopausal women. Recently her particular area of focus has been weight control of different diseases, supplements of active compounds of photochemistry of natural plants to prevent or treated many diseases.
Mervat A. El-Sherif
Mervat A. El-Sherif, PhD, is a post-doctoral of the Faculty of Science at University of Jouf Saudi Arabia. Her area of expert food technology and nutrition. Her research interests are food technology of edible plants to supply target groups.
Sahar B. Gomma
Sahar B. Gomma, PhD, is a researcher of the Department of biochemistry of National Organization for Drug Control and Research (NODCAR)- Giza 12553- (Egypt). Her research interests are biochemistry and drug interactions.
Seham S. Kassem
Seham S. Kasam, PhD, is a researcher of National Research Center- P.O. Box 12622- Dokki- Cairo- Egypt. Research Interest has been food science and technology for management of many diseases.
Madeha M. Abdelkader
Madeha M. Abdelkader, PhD, is a researcher of National Research Center- P.O. Box 12622- Dokki-Cairo- Egypt. Research Interest has been food science and technology for management of many diseases.