The role of single-nucleotide polymorphisms of the 8q24 chromosome region in patients with concomitant bladder and prostate cancer

Abstract

Objective

To assess whether single-nucleotide polymorphisms (SNPs) of the 8q24 chromosome region are associated with recurrence-free survival (RFS) after radical cystoprostatectomy (RC) in patients with concomitant bladder (BC) and prostate cancer (PC).

Materials and methods

A cohort of thirty-six patients treated with RC and pelvic lymph node dissection and histologically exhibited invasive BC and incidental PC. Using Sanger sequencing, a total of seven SNPs in the androgen-responsive element of the promoter region of the following genes were assessed in tumor-free lymph nodes and correlated with oncological outcomes: PSCA (rs2294008, rs2978974, rs1045531, rs3736001), MYC (rs6983267), FXBO32 (rs7830622), and MIR151A (rs14974929). The median follow-up was 26 months (range: 4–68).

Results

In a dominant model, patients exhibiting rs2978974 as a minor allelic variant of the PSCA gene had worse RFS (32 vs. 75%, p = 0.015). No associations were found for the other SNPs.

Conclusions

These data suggest that the rs2978974 of the PSCA gene correlates with inferior BC-specific RFS after RC and should be further evaluated in larger studies.

Keywords:

• Bladder cancer
• PSCA
• radical cystectomy
• recurrence
• rs2978974
• SNP

Acknowledgments

We thank Marita Munz for the technical support during the study

Disclosure statement

All authors report no conflicts of interest in relation to this study.

Figure 1. Kaplan–Meier analysis on BC-specific RFS in the 36 patients with concomitant BC and PC as a function of the minor allelic variant (T) rs2978974 of the PSCA gene (CC vs. CT/TT). The number of patients at risk of BC recurrence at specific post-operative time intervals is shown below the graph.