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Applied Neuropsychology: Adult Volume 29, 2022 - Issue 1
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Articles

The efficacy of gray matter atrophy and cognitive assessment in differentiation of aMCI and naMCI

Ruomeng Qina Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaORCID Iconhttps://orcid.org/0000-0001-7961-1602View further author information
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Mengchun Lia Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Rong Luoa Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Qing Yea Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Caimei Luoa Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Haifeng Chena Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Lai Qiana Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Xiaolei Zhua Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Feng Baia Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Bing Zhanga Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Renyuan Liua Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaView further author information
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Hui Zhaoa Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaCorrespondence[email protected]
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Yun Xua Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China;b Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China;c Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China;d Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaCorrespondence[email protected]
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Pages 83-89 | Published online: 16 Jan 2020
 
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Abstract

Background

Mild cognitive impairment (MCI) is a heterogeneous entity that can be categorized into related but different subtypes. In this study, we analyzed the gray matter structural changes of amnestic MCI (aMCI) and non-amnestic MCI (naMCI), and how it resulted in diverse cognitive impairment.

Methods

Altogether 77 individuals were recruited, including 28 cognitively normal controls (NC), 25 naMCI subjects, and 24 aMCI subjects. All participants underwent a 3.0 T magnetic resonance (MR) scan and a detailed neuropsychological examination. Cortical thickness and subcortical nuclei volume were extracted by Freesurfer software and compared among groups. The areas with significant differences were further analyzed by general linear regression to identify the risk factors of each cognitive impairment subtypes.

Results

Significant differences were observed in bilateral hippocampi, amygdala, thalamus, accumbens, left transverse temporal gyrus and left precuneus among groups. AMCI and naMCI were significantly different in the right hippocampus, bilateral amygdala, left precuneus, and left transverse temporal gyrus. Linear regression analysis revealed that the atrophy of left precuneus was a risk factor of memory, executive function (EF) and visuospatial impairment (p < 0.001). The atrophy of left amygdala, right accumbens and left thalamus were risk factors of memory, EF and language impairment respectively (p < 0.05).

Conclusions

These findings confirmed that different gray matter structural changes could lead to specific neuropsychological features in MCI subtypes. Thorough understanding of MCI subtypes and the underlying pathology would be beneficial for precise diagnosis and intervention.

Additional information

Funding

This work was supported partly by grants from the National Natural Science Foundation of China [81771157], Jiangsu Province “333” project, Nanjing Health Young Talent Project [QRX17001], and Nanjing Medical Science and technique Development Foundation.

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