IL-1R1 rs6755229 polymorphism is related to death in patients undergoing major surgery who develop septic shock: a retrospective study

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Acknowledgments

This study would not have been possible without the collaboration of all the patients, medical and nursery staff, and data managers who have taken part in the project. We want to acknowledge the patients in this study for their participation and to the laboratory of Dr. Jesus F Bermejo-Martin for the collection of clinical samples used in this work. The authors also thank the Spanish National Genotyping Center (CEGENPRB2-ISCIII) for providing SNP genotyping services (http://www.cegen.org).

Ethical approval and consent to participate

The study was conducted according to the Declaration of Helsinki and was approved by the Ethics Committee of Hospital Clínico Universitario (Valladolid) and Instituto de Salud Carlos III (Majadahonda). All participants provided written informed consent before sample collection. When a patient was unable to sign, a family member or legal representative of the patient gave the approval.

Author contributions

Funding body: ET and SR.

Study concept and design: MAJS, ET, and SR.

Patients’ selection and clinical data acquisition: EGS, RLH, MLL, MHR, BSQ, EGP, ET.

Sample preparation, DNA isolation, and genotyping: MAJS, EJVA.

Statistical analysis and interpretation of data: FPG, MAJS, and SR.

Writing of the manuscript: FPG, MAJS, and SR.

Critical revision of the manuscript for relevant intellectual content: AFR and ET.

Supervision and visualization: SR.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.

Additional information

Funding

This work has been supported by grants given by Instituto de Salud Carlos III [grant number PI18/01238 to ET], “Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon” [grant number VA321P18, GRS 1922/A/19, GRS 2057/A/19 to ET], Fundación Ramón Areces [grant number CIVP19A5953], and PFIZER [grant number CT25-ESP01-01 to SR]. MAJS and AFR are supported by “Instituto de Salud Carlos III” [grant numbers CP17CIII/00007 and CPII20CIII/001, respectively]. CEGEN is supported by grant [PT13/0001, ISCIII-SGEFI/FEDER].