Facile route for the synthesis and cytotoxic effect of 2-amino-4H-benzo[b]pyran derivatives in aqueous media using copper oxide nanoparticles decorated on cellulose nanocrystals as heterogeneous catalyst

Abstract

A simple, facile, green eco-friendly one pot synthesis of 2-amino-4H-benzo[b]pyrans derivatives catalyzed by copper oxide nanoparticles decorated on cellulose nanocrystals (CuO-CNs), a biodegradable matrice in aqueous media at room temperature is reported with excellent yields. The catalyst is recycled six times without significant loss in catalytic activity. Smaller E-factor and higher atom economy makes this protocol a true green and sustainable one. Cytotoxic effects of synthesized 2-amino-4H-benzo[b]pyrans derivatives are assayed with standard MTT colorimetric procedure against the human breast adenocarcinoma cell lines (MCF7) and showed nearly mild to moderate cell line inhibition at 125 µM tested dose.

Graphical Abstract

Keywords:

• Cellulose nanocrystals
• copper oxide nanoparticles
• condensation
• heterogeneous catalyst
• MCF-7 cell lines
• 2-amino-4H-benzo[b]pyrans

Acknowledgements

The authors acknowledge SAIF, Cochin for TEM, ICP-AES and Elemental analyses. Karunya Deemed University, Coimbatore for XRD, SEM and EDAX. VIT, Chennai for proton NMR. ANJA College for FT-IR and KSN College of Pharmaceutical, Coimbatore for Cytotoxic analysis.