Assessment of structural and cytotoxic properties of cobalt ferrite nanoparticles for biomedical applications

Abstract

Cobalt ferrite (CoFe₂O₄) has numerous desirable features such as high anisotropy, good magnetic saturation, large coercivity and high mechanical strength. These remarkable characteristics provide extensive employment for their wide application from industrial to biomedical. The present study aims to evaluate the crystal properties, particle size, and morphology of CoFe₂O₄ nanoparticles prepared by the thermal treatment method and investigates their biocompatibility. XRD and FTIR analyses demonstrated that CoFe₂O₄ nanoparticles have an inverse cubic spinel crystalline structure. The average size of spherical CoFe₂O₄ nanoparticles was confirmed by SEM analysis as 58 nm. The cytotoxic effect of CoFe₂O₄ nanoparticles was evaluated in L929 cells by using the XTT cell viability assay. After 24 h treatment of CoFe₂O₄ nanoparticles with a concentration between 10 and 1000 µg/ml, the viability of L929 cells did not significantly decrease. It is concluded that growth CoFe₂O₄ nanoparticles are beneficial materials for use in various biomedical applications.

KEYWORDS:

• Nanoparticle
• cobalt ferrite
• cytotoxicity
• XTT assay

Acknowledgments

The authors would like to thank Naime Didem Kahya for her support in terms of the synthesis of the cobalt ferrite nanoparticles.