Comparison of efficacy of nanoparticles synthesized from leaves and flowers of Russelia equisitiformis

Abstract

The present study was focused on synthesis of silver nanoparticles using Russelia equisitiformis plant (RelAgNps) and flower extracts (RefAgNps). Thus, the nanoparticles synthesis was confirmed using UV spectrometry and the FT-IR results showed the presence of similar compounds in the plant extract and FESEM-EDAX reveals the size, shape, and elemental composition of synthesized nanoparticles. The antioxidant activity of the RefAgNps from flower extract and RelAgNps from leaf extract was observed at the concentration of 25 μg/mL but the percentage of antioxidant activity of flower extract was comparatively higher than the leaf extract. This plant is also known to have antidiabetic activity and thus leaf extract and flower extract mediated nanoparticles is also known to have alpha amylase inhibition activity at the concentration of 12.5 and 100 μg/mL, respectively. Molecular docking of the plant compounds10-O-cinnamoyl sinuatol and rehmaglutin B were docked with alpha amylase enzyme proves the same with the binding energy of −9.1 kcal/mol. Thus, to the best of our knowledge this is the first-time nanoparticles have been synthesized using R. equisitiformis flower and leaf extract and observed to have potent antioxidant and antidiabetic activity.

KEYWORDS:

• Russelia equisitiformis
• alpha amylase inhibition assay
• nanoparticles
• 10-O-cinnamoyl sinuatol
• rehmaglutin B

Acknowledgements

The authors are thankful to B.S. Abdur Rahman Institute of Science & Technology, Chennai for providing research facilities in School of Life sciences. Also, they acknowledge the Ministry of Science and Technology, Department of Science and Technology (KIRAN Division) (GoI), New Delhi (Ref No. DST/WOS-B/2018/1583-HFN (G)).

Conflict of interest

The authors have no conflict of interest.