Evaluation of the effects of hyaluronic acid on poly (3-hydroxybutyrate)/chitosan/carbon nanotubes electrospun scaffold: structure and mechanical properties

ABSTRACT

In this study, a combination of poly (3-hydroxybutyrate) (PHB), chitosan (Cs), multiwall carbon nanotubes (MWNTs), and different concentrations of Hyaluronic Acid (HA) were electrospun. The results showed that the produced nanofibers are uniform. Incorporation of HA, Cs and MWNTs reduced the water contact angle and made the scaffolds more hydrophilic. The porosity of the scaffolds was in the range of 80–88%. The presence of MWNTs increased the tensile strength of scaffolds and different concentrations of HA had no much diverse effects. In conclusion, the PHB-Cs-MWNTs-HA 10% electrospun scaffold could be a good candidate for cartilage tissue engineering applications.

Graphical abstract

KEYWORDS:

• Carbon nanotubes
• cartilage tissue engineering
• chitosan
• hyaluronic acid
• poly (3-hydroxybutyrate)

Additional information

Notes on contributors

Mohammad Nikbakht

Mohammad Nikbakht graduated in 2007 from Tehran University of Medical Sciences in the field of radiology. In 2014, he received his MSc of nanotechnology in medicine from Tehran University of Medical Sciences and is now the student of doctorate program in the field of nanotechnology in medicine in Tehran University of Medical Sciences.