![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
ABSTRACT
The current research presents the formulation of losartan potassium-loaded biomucoadhesive-floating beads using sodium alginate (matrix-former), linseed polysaccharide (biomucoadhesive polymer) and calcium silicate (floatation-improving material). These losartan potassium-loaded beads showed 63.86 ± 0.93 to 95.33 ± 2.14% drug entrapment efficiency, 1.44 ± 0.04 to 1.72 ± 0.08 mm bead-size and 0.65 ± 0.06 to 0.81 ± 0.06 g/cm3 density. The biomucoadhesive-floating beads were characterized by SEM, FTIR and p-XRD. In gastric pH, losartan potassium-loaded beads presented excellent buoyancy, in vitro drug releasing over 10 h and good biomucoadhesivity. These biomucoadhesive-floating beads could be profitable to prolong gastroretention with sustained drug releasing.
GRAPHICAL ABSTRACT
KEYWORDS:
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Notes on contributors
Smrutirekha Behera
Smurtirekha Behera (M. Pharm) is currently working as the Assistant Professor in Department of Pharmacy, Sainath University, Jharkhand. She has over 4 years of teaching and research experience in the field of pharmaceutical formulation.
Champak Kumar Ghatuary
Champak Kumar Ghatuary (M. Pharm) was working as the Assistant Professor in Department of Pharmacy, Plalamau Institute of Pharmacy, Daltonganj, Jharkhand. She has over 4 years of teaching and research experience in the field of pharmaceutical formulation.
Amit Kumar Nayak
Dr. Amit Kumar Nayak (M. Pharm, PhD) is working as a Professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Odisha, India. He has over 15 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 26 international books to his credit. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha.
Md Saquib Hasnain
Dr. Md Saquib Hasnain (M. Pharm, PhD) is currently working as the Professor and Principal of Plalamau Institute of Pharmacy, Daltonganj, Jharkhand and has more than 13 years of research experience in the field of drug delivery and pharmaceutical formulation. To date, he has authored over 80 publications in various high impact peer-reviewed journals and has more than 100 book chapters and 30 books to his credit. He was the member of several scientific societies such as the Royal Society of Chemistry in Great Britain), International Association of Environmental and Analytical Chemistry in Switzerland and the Swiss Chemical Society. Currently he is the member of American Association of Pharmaceutical Scientists.