Biopeptides with Neuroprotective Effect in the Treatment of Neuroinflammation Induced by Adiposity-based Chronic Disease

ABSTRACT

The advance in genomic and biotechnological sciences has redirected the way of doing nutrition, from a diet based on calories and nutrients, to the implementation of doses of specific bioactive compounds for the treatment of disease. That is, in addition to the nutritional value, a diet based on the biological effect of the food can be thought of as functional nutrition. Proteins and peptides with biological activity are important areas of study and development of new foods. The adiposity-based chronic disease (ABCD), represents an important public health problem. ABCD is characterized by a state of inflammation and chronic oxidative stress that leads to biochemical-metabolic alterations associated with resistance to leptin, insulin, endothelial dysfunction and neurodegeneration. Several studies have shown that neuroinflammation is induced subsequent to the development of ABCD that results in the involvement of various structures of the nervous system. Data from the main biopeptide bases were reviewed, in order to evaluate the potential neuroprotective effect of peptides that could be used in the prevention and treatment of neuroinflammation induced by ABCD.

KEYWORDS:

• Neuroprotection
• biopeptides
• central nervous system
• functional foods