^ΒN-Alkanoyl-5-Hydroxytryptamines (C_n-5HTs) in Coffee: A Review

ABSTRACT

^ΒN-alkanoyl-5-hydroxytryptamines (C_n-5HTs) are serotonin amides that contain saturated or unsaturated alkyl long chains. They can be found in the waxy layer that covers the coffee bean and are also present in the coffee brew, one of the most popular beverages in the world. These substances exhibit relevant biological activities, such as antinociceptive and neuroprotective, despite being responsible for the stomach irritation observed in some individuals after drinking coffee. This review depicts the extraction and quantification of C_n-5HTs in green and roasted coffee beans, and coffee brew. Additionally, it illustrates the biological activities, synthetic strategies, and products formed during the roasting of the coffee bean, regarding the serotonin amides.

KEYWORDS:

• Coffee
• C_n-5HTs
• N-acylated serotonin
• stomach-friendly coffee

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Authors would like to acknowledge Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) [142180/2020-3; 141330/2017-1; 304394/2017-3], Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) [88887.320176/2019-00], Fundação de Amparo à Pesquisa Estado do Rio de Janeiro (FAPERJ) [E-26/202.941/2017; E-26/202.763/2018; E-26/202.283/2019; E-26/200.862/2021], and Embrapa Café for financial support.