The Intricate Role of Mir-155 in Carcinogenesis: Potential Implications for Esophageal Cancer Research

Abstract

MiRNAs have immerged as essential modulators of key cellular procuresses involved in post-transcriptional regulation of the human transcriptome. They are essential components of complex regulatory networks that modulate most important physiological functions of cells. MicroRNA-155 (miR-155) is a multifaceted regulator of cell proliferation, cell cycle, development, immunity and inflammation that plays pivotal, and sometimes contradictory, roles in numerous cancers including esophageal cancer. Here, we review the intricate role of miR-155 in cancer by exemplifying carcinogenesis of various tumors, focusing on recent findings that may provide a link between miR-155 and esophageal cancer-related pathways.

Keywords:

• apoptosis
• biomarker
• esophageal cancer
• inflammation
• miR-155
• NF-κB signaling
• P53
• target gene

Financial & competing interests disclosure

This work was supported by a grant from the research deputy of Tehran University of Medical Sciences (TUMS; grant no. 28336). The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

No writing assistance was utilized in the production of this manuscript.