The Impact of Monocyte to High-Density Lipoprotein Ratio on Reduced Renal Function: Insights From A Large Population

Abstract

Aim: To investigate whether monocyte to HDL cholesterol ratio (MHR) can improve the risk stratification of reduced renal function by estimating atherosclerosis. Patients & methods: The cross-sectional study included 8159 subjects (males: 45.73%, mean age: 54.12 years) from Northeast China in 2013. Results: Each standard deviation increase of MHR brought 42.9% additional risk of reduced renal function in males. In females, MHR strongly correlated with reduced renal function before it reached a breakpoint (MHR = 0.25). Additionally, net reclassification improvement identified the value of MHR (0.199; 95% CI: 0.030–0.369; p = 0.021) to improve the risk classification of renal function reduction. Conclusion: This study implicates that MHR is independently associated with reduced renal function and can refine the risk stratification of renal function reduction.

Keywords:

• atherosclerosis
• inflammation
• lipid accumulation
• monocyte to high-density lipoprotein cholesterol ratio
• reduced renal function

Acknowledgements

We would like to express our gratitude to all those who exert their effects in achieving this study.

Author contributions

In this study, WR Shi and HY Wang did the study design, statistical analyses and results interpretation. S Chen, XF Guo and Z Li participated as analyzing and resolving difficulties of analytic strategies and results discussion. Finally, YX Sun functioned as final reviewer and corresponding author. All authors read and approved the final manuscript.

Financial & competing interests disclosure

This study was supported by grants from the ‘Thirteenth Five-Year program funds (The National Key Research and Development Program of China, grant number 2017YFC1307600)’. The founder provided financial support for our survey, but did not interfere with the design, operation and analysis of the study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The Ethics Committee of China Medical University (Shenyang, China) approved our study protocol. Written informed consent was obtained from every participant; if disabled, informed consent was acquired from the proxies of the participant.

Additional information

Funding

This study was supported by grants from the ‘Thirteenth Five-Year program funds (The National Key Research and Development Program of China, grant number 2017YFC1307600)’. The founder provided financial support for our survey, but did not interfere with the design, operation and analysis of the study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.