Osteoprotegerin and Osteopontin Levels, But Not Gene Polymorphisms, Predict Mortality in Cardiovascular Diseases

Abstract

Aim: This study aims to investigate whether osteoprotegerin (OPG) or osteopontin (OPN) single nucleotide polymorphisms (SNPs) will predict survival. Materials & methods: This study enrolled 617 participants undergoing health examination, 536 coronary artery disease (CAD) patients and 86 peripheral artery disease (PAD) patients. Genotypes of OPG SNP rs2073618 and OPN SNP rs11730582 were determined. OPG and OPN levels were measured. Results: In both CAD and PAD populations, high OPG and OPN levels were strong predictors of all-cause death. The OPG rs2073618 CC genotype and the OPN rs11730582 TT genotype did not predict mortality. Conclusion: High OPG and high OPN levels, but not OPG rs2073618 CC genotype or OPN rs11730582 TT genotype, were strong predictors of mortality in both CAD and PAD patients.

Keywords:

• coronary artery disease
• osteopontin
• osteoprotegerin
• peripheral artery disease
• SNP

Financial & competing interests disclosure

Our study was supported by grants from Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (TCRD-TPE-106-C1-3, the first year); Tzu Chi University (TCMMP 104-06-03); Buddhist Tzu Chi Medical Foundation (TCMF-A 106-01-16) and National Science Council, Taiwan (MOST 104-2314-B-303-013-MY3). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

Ethics committees approved the studies and written informed consent was provided by all study participants.

Additional information

Funding

Our study was supported by grants from Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (TCRD-TPE-106-C1-3, the first year); Tzu Chi University (TCMMP 104-06-03); Buddhist Tzu Chi Medical Foundation (TCMF-A 106-01-16) and National Science Council, Taiwan (MOST 104-2314-B-303-013-MY3). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.