The Relationship Between CYP7A1 Polymorphisms, Coronary Artery Disease & Serum Lipid Markers

Abstract

Polymorphic variants of the CYP7A1 gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. Method: We studied haplotype-tagging single nucleotide polymorphisms of CYP7A1 in the Caucasian population and if they are associated with CAD, its symptoms, and any of its risk factors. Results: We did not find the genetic variants of CYP7A1 to be associated with an increased risk of CAD. However, we did find that the common rs3808607 variant is associated with modified concentrations of serum total cholesterol and LDL. We also found that the C allele and the CC genotype of the rs11786580 are more frequent in patients with myocardial infarction. This association was especially strong after the group differentiation by sex.

Keywords:

• coronary artery disease
• CYP7A1
• low-density lipoprotein
• myocardial infarction
• total cholesterol

Financial & competing interests disclosure

This research was funded by Medical University of Silesia grants numbers: KNW-1-015/P/1/0; KNW-1-016/10; KNW-2-01-018/10; KNW-1-004/P/2/0; KNW-2-093/09. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The study protocol was approved by the Ethics Committee of the Medical University of Silesia in Katowice, Poland. All subjects submitted informed consent.

Additional information

Funding

This research was funded by Medical University of Silesia grants numbers: KNW-1-015/P/1/0; KNW-1-016/10; KNW-2-01-018/10; KNW-1-004/P/2/0; KNW-2-093/09. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.