Akp and Ggt Level Can Provide An Early Prediction of First-Line Treatment Efficacy in Colorectal Cancer Patients with Hepatic Metastases

Abstract

Aim: It is important to early evaluate or predict the efficacy to avoid ineffective treatment for most colorectal cancer (CRC) patients with liver metastases. Patients & methods: The medical records of 440 patients with histologically confirmed primary CRC admitted to the Fudan University Shanghai Cancer Center were reviewed. Results: High baseline serum alkaline phosphatase (AKP) and γ-glutamyl transferase (GGT) is associated with worse overall survival. In patients with a high serum AKP and GGT a decreased percentage had high objective response rate and better progression-free survival. Conclusion: Measuring the changes of serum AKP or GGT in CRC patients with hepatic metastases before and after the first cycle of treatment is a convenient, fast and economical way to early predict antitumor treatment efficacy.

Keywords:

• alkaline phosphatase
• colorectal cancer
• γ-glutamyl transferase
• hepatic metastases
• therapy efficacy

Author contributions

All the authors were involved in the conception of the study, and revised and approved the final manuscript. All the authors take the responsibility for publishing this paper. Z Gong, X Zhang, Q Geng, X Sheng, W Li, M Huang, Z Chen and W Zhang collected data. Z Gong and X Sheng were responsible for the analysis. W Guo and W Zhang were responsible for the supervision. Z Gong and X Zhang were involved in the writing. Z Gong edited the manuscript.

Acknowledgements

The authors acknowledge all the patients who were enrolled in this study.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The study has been approved by the Fudan University Shanghai Cancer Center ethics committee.

Data sharing statement

FUSCC cohort data used and analyzed during the current study are available from the corresponding author on reasonable request.