Abstract
Objective: This study is to explore the predictive value of erythrocyte-derived microparticles (ErMPs) in patients with acute coronary syndrome (ACS). Materials & methods: Total 305 subjects were enrolled and divided into the control group and ACS group. Flow cytometry was used to detect the ErMPs. The Gensini score was calculated based on the results of the coronary angiography. Results: Compared with that in the control group, the ErMPs concentration in the ACS group increased significantly and the concentration of ErMPs was correlated with the ACS risk. The concentration of ErMPs and the percentage of ErMPs were positively correlated with the Gensini score. Conclusion: ErMPs may be a new biomarker for predicting the ACS risk and the coronary artery disease severity.
Author contributions
H-x Liao performed the experiments, data analyses and wrote the manuscript. L-l Meng, X Yu, M Song, G-k Shang and D Wang contributed significantly to analysis, manuscript preparation, visualization and investigation. Z-h Wang and W Zhang helped perform the analysis with constructive discussions and project administration. M Zhong and H Zhu contributed to the conception of the study, provided overall guidance, interpretation of the results and writing, review and editing.
Acknowledgements
The authors sincerely thanked their colleagues, who participated in this study with great cooperation and support.
Financial & competing interests disclosure
This work was supported by research grants from the National Natural Science Foundation of China (81900332, 81873534, 81702194, 81600633, 81670411, 81570400, 81801953, 81470560, 81471036), the Key research and development program of Shandong Province (2019GSF108041, 2018GSF118002, 2018GSF118017, 2017GSF18156), and the Natural Science Foundation of Shandong Province (ZR2019QH010, ZR2014HQ037, ZR2017BH023). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The protocol for this study was examined and approved by the Ethics Review Board of the Qilu Hospital of Shandong University (license no: KYLL-2018-087), and it conforms to the ethical guidelines of the Declaration of Helsinki. All the subjects provided informed consent for study participation.