Serum Prealbumin As A Predictor of Adverse Outcomes in Patients with Heart Failure: A Systematic Review and Meta-Analysis

Abstract

Aim: To evaluate the association of serum prealbumin level with adverse outcomes in heart failure (HF) patients by conducting a meta-analysis. Methods: A comprehensive literature search was conducted in both international and Chinese databases to identify the cohort studies that reported the association of serum prealbumin level with all-cause mortality and composite endpoints of death/heart failure readmission in HF patients. Results: Eight studies involving 2439 patients were eligible. Low prealbumin level was associated with higher risk of all-cause mortality (adjusted risk ratio [RR] 1.89; 95% CI: 1.35–2.65) and composite endpoints (adjusted RR 3.08; 95% CI: 1.43–6.64). Conclusions: Low serum prealbumin level may be an independent predictor of all-cause mortality/heart failure readmission in HF patients.

Keywords:

• all-cause mortality
• heart failure
• meta-analysis
• prealbumin
• readmission

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.