Emerging Roles of HOTAIR LncRNA in the Pathogenesis and Prognosis of Cardiovascular Diseases

Highlights

HOTAIR, a long noncoding RNA, plays a role in the regulation of proteins involved in the pathogenesis of cardiovascular disease. Furthermore, it has been identified as a biomarker of this type of disease. Several factors and cells contribute to atherosclerosis, a progressive disease. However, the prognosis of HOTAIR in this disease varies depending on the path in which it plays a role. For this condition, there is no single prognosis to consider.

Cardiovascular disease (CVD) stands as a major cause of global mortality, and its early diagnosis necessitates a comprehensive understanding of molecular aspects. Long noncoding RNAs, such as lncRNA HOTAIR, have gained attention for their role in disease pathogenesis. This article scrutinizes the involvement of HOTAIR in CVD, evaluating research on both physiological and pathological processes within the cardiovascular system. We have demonstrated that this lncRNA has a distinct influence on the pathogenesis of CVD. HOTAIR demonstrates a spectrum of beneficial and potentially harmful effects on critical processes such as apoptosis, oxidative stress and inflammation. Diverse conditions elicit distinct prognostic outcomes. Furthermore, the expression profile of HOTAIR in certain CVD suggests potential for its use as a diagnostic biomarker.

Keywords: :

• cardiovascular disease
• HOTAIR
• lncRNA
• pathogenesis
• prognosis

Author contributions

D Purrahman and H Haybar were the principal investigators of the study. H Hadi and N Saki were included in preparing the concept and design. MR Mahmoudian-Sani and N Saki revisited the manuscript and critically evaluated the intellectual contents. All authors participated in preparing the final draft of the manuscript, revised the manuscript and critically evaluated the intellectual contents. All authors have read and approved the content of the manuscript and confirmed the accuracy or integrity of any part of the work.

Financial disclosure

Ahvaz Jundishapur University of Medical Sciences (Ahvaz, Iran). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.