Abstract
Exosomes are secreted nanovesicles that are able to transfer their cargo (such as miRNAs) between cells. To determine to what extent exosomes and exosomal miRNAs are involved in the pathogenesis, progression and diagnosis of viral infections. The scientific literature (PubMed and Google Scholar) was searched from 1970 to 2019. The complex biogenesis of exosomes and miRNAs was reviewed. Exosomes contain both viral and host miRNAs that can be used as diagnostic biomarkers for viral diseases. Viral proteins can alter miRNAs, and conversely miRNAs can alter the host response to viral infections in a positive or negative manner. It is expected that exosomal miRNAs will be increasingly used for diagnosis, monitoring and even treatment of viral infections.
Financial & competing interests disclosure
MR Hamblin was supported by US NIH Grants R01AI050875 and R21AI121700. MR Hamblin declares the following potential conflicts of interest. Scientific Advisory Boards: Transdermal Cap Inc., Cleveland, OH, USA; BeWell Global Inc., Wan Chai, Hong Kong; Hologenix Inc., Santa Monica, CA, USA; LumiThera Inc., Poulsbo, WA, USA; Vielight, Toronto, Canada; Bright Photomedicine, Sao Paulo, Brazil; Quantum Dynamics LLC, Cambridge, MA, USA; Global Photon Inc., Bee Cave, TX, USA; Medical Coherence, Boston MA, USA; NeuroThera, Newark, DE, USA; JOOVV Inc., Minneapolis, St. Paul, MN, USA; AIRx Medical, Pleasanton, CA, USA; FIR Industries, Inc., Ramsey, NJ, USA; UVLRx Therapeutics, Oldsmar, FL, USA; Ultralux UV Inc., Lansing, MI, USA; Illumiheal & Petthera, Shoreline, WA, USA; MB Lasertherapy, Houston, TX, USA; ARRC LED, San Clemente, CA, USA; Varuna Biomedical Corp., Incline Village, NV, USA; Niraxx Light Therapeutics, Inc., Boston, MA, USA. Consulting; Lexington Int., Boca Raton, FL, USA; USHIO Corp., Japan; Merck KGaA, Darmstadt, Germany; Philips Electronics Nederland B.V. Eindhoven, Netherlands; Johnson & Johnson Inc., Philadelphia, PA, USA; Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany. Stockholdings: Global Photon Inc., Bee Cave, TX, USA; Mitonix, Newark, DE, USA. The other authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.