1,271
Views
0
CrossRef citations to date
0
Altmetric
Short Communication

Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes

, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 919-925 | Received 04 Dec 2020, Accepted 22 Apr 2021, Published online: 05 May 2021
 

Abstract

Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patients. Materials & methods: DNA methylation was analyzed in blood from newly diagnosed T2D patients in All New Diabetics in Scania (ANDIS) and a replication cohort All New Diabetics in Uppsala County (ANDiU). Results: Seventy-nine sites were differentially methylated between cases on statins and controls (false discovery rate <5%) in ANDIS. These include previously statin-associated methylation sites annotated to DHCR24 (cg17901584), ABCG1 (cg27243685) and SC4MOL (cg05119988). Differential methylation of two sites related to cholesterol biosynthesis and immune response, cg17901584 (DHCR24) and cg23011663 (ARIH2), were replicated in ANDiU. Conclusion: Statin therapy associates with epigenetic modifications in T2D patients.

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/epi-2020-0442

Acknowledgments

We thank M Sterner and the Swegene Centre for Integrative Biology at Lund University (SCIBLU) genomics facility at Lund University, Malmö, Sweden.

Financial & competing interests disclosure

Novo Nordisk foundation, Swedish Research Council, Region Skåne (ALF), H2020-Marie Skłodowska-Curie grant agreement number 706081 (EpiHope), Hjärt Lund fonden, Exodiab, Swedish Foundation for Strategic Research for IRC15-0067, Swedish Diabetes Foundation, European Research Council-Consolidator (ERC-Co) grant (PAINTBOX no.: 725840). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Data sharing statement

Data are deposited at the LUDC repository (www.LUDC/lu.se/resources/repository) and are available upon request.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 130.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.