Developments in High-Throughput Functional Epigenomics: Crispr-Single-Cell Assay for Transposase-Accessible Chromatin using Sequencing Screens

Tweetable abstract

CRISPR-scATAC-seq screens pave the way for high-throughput functional epigenomics by linking perturbations to a broad view of epigenetic state and messages hidden within accessible sequences.

Keywords::

• ATAC
• CRISPR
• functional genomics
• genetic screens
• single cell

Acknowledgements

Work in our group on pediatric brain tumors is​ partly supported by generous donations from the Patrick Bayly Marsano Foundation, the Children’s Brain Tumor Project Foundation, and the Ty Louis Campbell Foundation. REY was a 2020 Rudin Foundation Fellow.

Financial&competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

No writing assistance was utilized in the production of this manuscript.